| CatalogCode: | NB100-1821 |
| ProductName: | MCM4 Antibody |
| Product Description: | Goat Polyclonal anti-MCM4 |
| Clonality: | Polyclonal |
| Immunogen: | The epitope recognized maps to a region between residues 325 and 375 of human Minichromosome Maintenance 4 using the numbering given in entry NP_005905.2 (GeneID 4173). |
| CrossReactivity: | This antibody cross-reacts with human. Other species have not been tested. |
| Packaging: | 0.1 ml of affinity purified antisera. The antibody was affinity purified using an epitope specific for the protein, immobilized on solid support. |
| Uses: | This antibody is useful for immunohistochemistry. No other applications have been tested. Suggested working dilution: *Immunohistochemistry: 1:100-1:500 (FFPE sections)Epitope exposure is recommended.Epitope exposure with citrate buffer will enhance staining.Likely to work with frozen sections.*The investigator should determine the optimal working dilution for a specific application. |
| Background: | The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Affinity purified |
| Host_Name: | Goat |
| Buffer: | Tris-buffered Saline containing 0.1% BSA with 0.09% Sodium Azide |
| ListPrice: | 350 |
| AppSummary: | IHC |
| SpeciesSummary: | Hu |
| ALTnames: | anti-P1-CDC21 antibody, anti-CDC21 homolog antibody, anti-CDC54 antibody, anti-DNA replication licensing factor MCM4 antibody |
| ProteinTarget: | MCM4 |
| PackageSize: | 0.1 ml |
| Gene_Id: | 4173 |
| Omim_ID: | NB100-1822 |
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