| CatalogCode: | NB100-1820 |
| ProductName: | MCM3 Antibody |
| Product Description: | Goat Polyclonal anti-MCM3 |
| Clonality: | Polyclonal |
| Immunogen: | The epitope recognized maps to a region between residues 500 and 550 of human Minichromosome Maintenance 3 using the numbering given in entry NP_002379.2 (GeneID 4172). |
| CrossReactivity: | This antibody cross-reacts with human. Other species have not been tested. |
| Packaging: | 0.1 ml of affinity purified antisera. The antibody was affinity purified using an epitope specific for the protein, immobilized on solid support. |
| Uses: | This antibody is useful for immunohistochemistry. No other applications have been tested. Suggested working dilution: *Immunohistochemistry: 1:100-1:500 (FFPE sections)Epitope exposure is recommended.Epitope exposure with citrate buffer will enhance staining.Likely to work with frozen sections.*The investigator should determine the optimal working dilution for a specific application. |
| Background: | The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with, and thus is acetlyated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. (referenced from Entrez Gene) |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Affinity purified |
| Host_Name: | Goat |
| Buffer: | Tris-buffered Saline containing 0.1% BSA with 0.09% Sodium Azide |
| ListPrice: | 350 |
| AppSummary: | IHC |
| SpeciesSummary: | Hu |
| ALTnames: | anti-RLFB antibody, anti-replication licensing factor antibody, anti-beta subunit antibody, anti-P1-MCM3 antibody, anti-P1 Protein antibody, anti-DNA polymerase alpha holoenzyme-associated protein P1 antibody, anti-P102 protein antibody, anti-HCC5 antibody, anti-human cervical cancer proto-oncogene 5 antibody |
| ProteinTarget: | MCM3 |
| PackageSize: | 0.1 ml |
| Gene_Id: | 4172 |
| Omim_ID: | NB100-2375 |
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