| request information: |
|
| Catalog Code: | NB100-1803 |
| Product Name: | 53BP1 Phosphospecific Antibody |
| Product Description: | Rabbit Polyclonal anti-53BP1 [Ser25] |
| Clonality: | Polyclonal |
| ListPrice: | 325 |
| Gene ID: | 7158 |
| Concentration: | 0.2 mg/ml |
| Immunogen: | Immunogen for this antibody was a phosphorylated synthetic peptide, which represented a portion of human p53 Binding Protein 1 (GeneID 7158) around serine 25 according to the numbering given in entry NP_005648.1. |
| Cross Reactivity: | Human and Mouse. |
| Packaging: | 0.1 ml Immunogen affinity purified Rabbit antisera. |
| Uses: | This antibody is useful for Western blot and immunoprecipitation. No other applications have been tested. Suggested working dilution: *Western blot: 1:1,000-1:10,000 Immunoprecipitation: 1-4 ug/ml of lysateImmunohistochemistry: Not Tested *The investigator should determine the optimal working dilution for a specific application. |
| Background: | P53-binding protein 1 (53BP1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, it is phosphorylated and relocalizes to the presumptive sites of damage, specifically, double-strand breaks. This also suggests a role in DNA repair, maintaining genomic stability. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Host Name: | Rabbit |
| Buffer: | Tris-buffered Saline containing 0.1% BSA |
| Application Summary: | immunoprecipitation 1 to 4 ug/ml, Western Blot 1:1,000 to 1:10,000 |
| Species Summary: | Hu, Mu |
| Alternate Names: | anti-53BP1 antibody, anti-53BP-1 antibody, anti-TP53BP1 antibody, anti-Tumor Protein p53 Binding Protein 1 antibody |
| Package Size: | 0.02 mg |
| Preservative: | 0.09% Sodium Azide |
| Phosphorylated: | Ser25 |
| Notes Main: | 53BP1 [S25] Blocking Peptide may be available (50ug/$ 150). Please inquire. |
order or
more information: | company product webpage |