| Catalog Code: | NB100-177 |
| Product Type: | Primary Antibody |
| Product Name: | RAD51C Antibody |
| List Price: | 275 |
| Clonality: | Monoclonal |
| Gene ID: | 5889 |
| Host: | Mouse |
| Clone: | 2H11/6 |
| Isotype: | IgG1 kappa |
| Product Description: | Mouse Monoclonal anti-RAD51C (2H11/6) |
| Cross Reactivity: | NB 100-177 recognizes human and mouse Rad51C. Other species have not been tested. NB 100-177 does not cross-react with Rad51B, Rad51D, Rad51, XRCC2, or XRCC3 in Western analysis. |
| Species Summary: | Hu, Mu |
| Background: | The Rad51 DNA repair protein is a key component of the double-strand break repair pathway and is essential for mitotic and meiotic recombination and genomic stability. Five human Rad51 homologs have been identified: XRCC2, XRCC3, Rad51B, Rad51C, and Rad51 |
| Alternate Names: | anti-DNA repair protein Rad51 homolog 3 antibody, anti-Rad51 homolog C (S. cerevisiae) antibody, anti-Rad51L2 antibody, anti-Yeast Rad51 homolog 3 antibody |
| Immunogen: | His-tagged human Rad51C, over-expressed in E. coli. |
| Specificity: | This antibody is specific for Rad51C. |
| Purity: | IgG purified |
| Buffer: | PBS (physiological pH) |
| Packaging: | 0.1 ml IgG purified Mouse ascites. |
| Package Size: | 0.1 ml |
| Uses: | By Western blot, this antibody recognizes a band at ~40 kDa. Preliminary feedback has been negative for immunofluorescence on 4% PFA-fixed human cell lines (H1299 and MCF7). |
| Application Summary: | WB, ECL, IF |
| Storage: | Store at 4C. Do not freeze. |
| Product References: | 1. Masson, et al. Identification and purification of two distinct complexes containing the five RAD51 paralogs. Genes & Dev. 15: 3296-3307 (2001) [Immunoprecipitation, human] 2. Maacke, H. Autoantibodies in sera of pancreatic cancer patients identif |
| Novus References: | 1. Fan, R., et al. Defective Strand Break Repair after DNA Damage in Prostate Cancer Cells: Implications for Genetic Instability and Prostate Cancer Progression. Cancer Res. 64: 8526-8533 (2004)2. Kuznetsov, et al. RAD51C deficiency in mice results in ear |
| Notes Main: | **NOTE: This antibody's form has been changed. It is now sold in its purified form. All lots, other than lots A and B, have been purified. |