| CatalogCode: | NB100-1744 |
| ProductName: | NSD1 Antibody |
| Product Description: | Rabbit Polyclonal anti-NSD1 |
| Clonality: | Polyclonal |
| Immunogen: | The epitope recognized maps to a region between residues 650 and 700 of human NSD1 using the numbering given in SwissProt entry Q96L73 (GeneID 64324). |
| CrossReactivity: | This antibody cross-reacts with human. Other species have not been tested. |
| Packaging: | 0.1 ml Affinity purified Rabbit antisera. |
| Uses: | This antibody is useful for immunohistochemistry. Epitope exposure is not recommended (citrate buffer may hinder staining). Likely to work with frozen sections. No other applications have been tested. Suggested working dilution: *Immunohistochemistry-FFPE: 1:100-1:500 *Optimal dilutions should be determined by the end user. |
| Background: | This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorac domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Two transcript variants encoding distinct isoforms have been identified for this gene. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Affinity purified |
| Host_Name: | Rabbit |
| Buffer: | Tris-buffered Saline containing 0.1% BSA |
| ListPrice: | 350 |
| AppSummary: | IHC |
| SpeciesSummary: | Hu |
| ALTnames: | anti-NSD1 antibody, anti-NSD-1 antibody, anti-nuclear receptor binding SET domain protein 1 antibody, anti-ARA267 antibody, anti-ARA-267 antibody, anti-androgen receptor-associated coregulator 267 antibody, anti-STO antibody, anti-SOTOS antibody, anti-Sotos syndrome antibody, anti-FLJ22263 antibody |
| ProteinTarget: | NSD1 |
| PackageSize: | 0.1 ml |
| Gene_Id: | 64324 |
| Omim_ID: | H00050814-A01 |
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