| Catalog Code: | NB100-1684 |
| Product Type: | Primary Antibody |
| Product Name: | PAK 1 + 2 + 3 Antibody |
| List Price: | 325 |
| Clonality: | Polyclonal |
| Gene ID: | 5058 |
| Host: | Rabbit |
| Isotype: | IgG |
| Product Description: | Rabbit Polyclonal anti-PAK 1 + 2 + 3 [Thr423] |
| Phosphorylated: | Thr423 |
| Cross Reactivity: | Cross-reacts with Human. Not yet tested in other species. |
| Species Summary: | Hu |
| Background: | P21-activated kinase (PAK) is actually a family of serine/threonine protein kinases, members of which are activated by small molecular weight GTPases. The three most common isoforms are PAK 1, PAK 2, and PAK 3 (also known as alpha PAK, gamma PAK, and beta |
| Immunogen: | Synthetic peptide: EQSKRSTpMVGTPY conjugated to KLH, corresponding to amino acids 413-433 of Human PAK 1, 408-428 of human PAK 2 and 411-431 of human PAK 3. |
| Specificity: | This phospho specific polyclonal antibody is specific for phosphorylated Threonine 423 of Human PAK 1 + 2 + 3. Reactivity with non-phosphorylated PAK 1 + 2 + 3 is less than 1% by ELISA. |
| Purity: | Immunogen affinity purified |
| Buffer: | Preservative: 0.01% Sodium Azide Constituents: 0.15M Sodium Chloride, 0.02M Potassium Phosphate. pH |
| Packaging: | 100 micrograms Liquid |
| Package Size: | 0.1 mg |
| Uses: | WB: Use at a dilution of 1/100. Detects a band of approximately 65 kDa. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Application Summary: | WB |
| General References: | General / background references:Kissil JL et al. Merlin phosphorylation by p21-activated kinase 2 and effects of phosphorylation on merlin localization. J Biol Chem 277:10394-9 (2002). Roig J et al. Cdc42-independent activation and transl |