| CatalogCode: | NB100-1601 |
| ProductName: | PPAR gamma 2 Antibody |
| Product Description: | Rabbit Polyclonal anti-PPAR gamma 2 |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide: IKKTETDMSLHPLLQ, corresponding to C-term amino acids 484-498 of PPAR gamma 2. This sequence is highly conserved in mouse, human and rat PPAR gamma 1, PPAR alpha and NUC1. |
| Specificity: | Reacts with rat recombinant PPAR alpha in Western blotting and recombinant mouse PPAR gamma 1 in immunoprecipitation. |
| CrossReactivity: | Cross-reacts with Mouse and Rat.Expected to cross-react with Human (100% identity with immunogen), Xenopus laevis (93% identity with immunogen), Cow (100% identity with immunogen), Chicken (100% identity with immunogen) and Pig (100% identity with immunogen) due to sequence homology. Not yet tested in other species. |
| Packaging: | 0.05 ml Whole antisera Rabbit antisera. |
| Uses: | Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Nuclear |
| Control: | Mouse 3T3-L1 cells |
| Background: | Peroxisome proliferators are non-genotoxic carcinogens which are purported to exert their effect on cells through their interaction with members of the nuclear hormone receptor family termed peroxisome proliferator activated receptors (PPAR's). Nuclear hormone receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate ligand. Studies indicate that PPAR's are activated by peroxisome proliferators such as clofibric acid, nafenopin, and WY-14,643, as well as by some fatty acids. It has also been shown that PPAR's can induce transcription of acyl coenzyme A oxidase & CYP450 A6 through interaction with specific response elements. PPAR, like several other nuclear hormone receptors, heterodimerizes with RXR |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Whole antisera |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| ListPrice: | 295 |
| AppSummary: | IP, WB |
| SpeciesSummary: | Mu, Rt |
| ALTnames: | anti-peroxisome proliferator activated receptor gamma 2 antibody; anti-PPAR-gamma 2 antibody |
| ProteinTarget: | PPAR gamma 2 |
| PackageSize: | 0.05 ml |
| GeneralRef: | General / background references:Braissant O et al. Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat. Endocrinology 137:354-66 (1996). Gimble JM et al. Peroxisome proliferator-activated receptor-gamma activation by thiazolidinediones induces adipogenesis in bone marrow stromal cells. Mol Pharmacol 50:1087-94 (1996). |
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