| CatalogCode: | NB100-1518 |
| ProductName: | Adiponectin Receptor 1 Antibody |
| Product Description: | Goat Polyclonal anti-Adiponectin Receptor 1 |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide RYGLEGGCTDDTLL, representing the C-Terminus of the human protein (residues 361-375), according to NP_057083.2. |
| CrossReactivity: | Human. Not yet tested in other species. |
| Packaging: | 0.1 mg Immunogen affinity purified Goat antisera. |
| Uses: | Peptide ELISA: antibody detection limit dilution 1:128,000. Western Blot: Approx 38kDa band observed in Human Muscle lysates (calculated MW of 42.6kDa according to NP_057083.2). Recommended concentration: 0.1-0.3µg/ml. |
| Background: | Gene ID: 51094 |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Goat |
| Buffer: | Tris-saline [pH7.3] with 0.5% BSA |
| ListPrice: | 295 |
| AppSummary: | ELISA, WB |
| SpeciesSummary: | Hu |
| ALTnames: | anti-ACDCR1 antibody, anti-ADIPOR1 antibody, anti-CGI-45 antibody, anti-CGI-45 protein antibody, anti-PAQR1 antibody |
| ProteinTarget: | Adiponectin Receptor 1 |
| PackageSize: | 0.1 mg |
| GeneralRef: | Yamauchi T et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 423:762-9 (2003). PubMed: 12802337 |
| NotesMain: | Acrp30 is a hormone secreted by adipocytes that acts as an antidiabetic and anti-atherogenic adipokine. Levels of adiponectin in the blood are decreased under conditions of obesity, insulin resistance and type 2 diabetes. Administration of adiponectin causes glucose-lowering effects and ameliorates insulin resistance in mice. Conversely, adiponectin-deficient mice exhibit insulin resistance and diabetes. This insulin-sensitizing effect of adiponectin seems to be mediated by an increase in fatty-acid oxidation through activation of AMP kinase and PPAR- . Cloning of complementary DNAs encoding adiponectin receptors 1 and 2 (AdipoR1 and AdipoR2) have shown that AdipoR1 is abundantly expressed in skeletal muscle, whereas AdipoR2 is predominantly expressed in the liver. These two adiponectin receptors are predicted to contain seven transmembrane domains, but are structurally and functionally distinct from G-protein-coupled receptors. Expression of AdipoR1/R2 or suppression of AdipoR1/R2 expression by small-interfering RNA supports our conclusion that they serve as receptors for globular and full-length adiponectin, and that they mediate increased AMP kinase and PPAR- ligand activities, as well as fatty-acid oxidation and glucose uptake by adiponectin. |
| Gene_Id: | 51094 |
| Omim_ID: | NB100-74347 |
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