| CatalogCode: | NB100-1512 |
| ProductName: | CHMP5 Antibody |
| Product Description: | Goat Polyclonal anti-CHMP5 |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide C-NKDGVLVDEFGLPQ, representing the C-Terminus of the human protein (residues 202-215), according to NP_057494.2. |
| Specificity: | Predicted to react with Human due to sequence homology.Not yet tested in other species. |
| CrossReactivity: | Predicted to react with Human due to sequence homology. Not yet tested in other species. |
| Packaging: | 0.1 mg Immunogen affinity purified Goat antisera. |
| Uses: | This antibody can be used for ELISA and Western Blot. In Western Blot, preliminary experiments in Human Bone Marrow, Lymph Node and Thymus lysates gave no specific signal but low background. Not tested in other applications. Recommended Starting Dilution:*ELISA (peptide): 1:32,000WB: 1ug/ml*Optimal dilutions should be determined by the end user. |
| Background: | **Please note, this product is one of a range of Investigative Grade antibodies, made against targets that have limited or no commercial antibodies available to them and for which there are no data on the expression of the protein in the range of common cell lines and tissues available to us. These antibodies are affinity purified using their peptide immunogen and are known to give low background staining in a western blot. However no additional claims are made for their ability to recognise native protein in any application CHMP5 is a component of the ESCRT-III complex, which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-III complex is probably involved in the concentration of MVB cargo. In case of infection, the HIV-1 virus takes advantage of the ESCRT-III complex for budding and exocytic cargoes of viral proteins. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Goat |
| Buffer: | Tris-saline containing 0.02% Na azide [pH7.3] with 0.5% BSA |
| ListPrice: | 195 |
| AppSummary: | ELISA, WB |
| SpeciesSummary: | Hu |
| ALTnames: | anti-C9orf83 antibody, anti-CGI 34 antibody, anti-Charged multivesicular body protein 5 antibody, anti-Chromatin modifying protein 5 antibody, anti-Chromosome 9 open reading frame 83 antibody, anti-HGNC:26942 antibody, anti-HSPC177 antibody, anti-hVps60 antibody, anti-PNAS 2 antibody, anti-SNF7 domain containing protein 2 antibody, anti-SNF7DC2 antibody, anti-Vacuolar protein sorting 60 antibody, anti-Vps60 antibody |
| ProteinTarget: | CHMP5 |
| PackageSize: | 0.1 mg |
| GeneralRef: | Ward DM et al. The role of LIP5 and CHMP5 in multivesicular body formation and HIV-1 budding in mammalian cells. J Biol Chem 280:10548-55 (2005). PubMed: 15644320 |
| NotesMain: | **Please note, this product is one of a range of Investigative Grade antibodies, made against targets that have limited or no commercial antibodies available to them and for which there are no data on the expression of the protein in the range of common cell lines and tissues available to us. These antibodies are affinity purified using their peptide immunogen and are known to give low background staining in a western blot. However no additional claims are made for their ability to recognise native protein in any application |
| Gene_Id: | 51510 |
| Omim_ID: | H00091782-B01 |
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