| CatalogCode: | | NB100-1483 |
| ProductName: | | Proteasome 26S S2 Antibody |
| Product Description: | | Goat Polyclonal anti-Proteasome 26S S2 |
| Clonality: | | Polyclonal |
| Immunogen: | | Synthetic peptide: C VILRKNPNYDL, representing the C-terminus of the human protein (residues 898-908), according to NP_002799. |
| CrossReactivity: | | Reacts with Human. Predicted to react with Mouse (100% identity with immunogen), Crab Eating Macaque Monkey (100% identity with immunogen) , Orangutan (100% identity with immunogen) and Pig (100% identity with immunogen) due to sequence homology. Not yet tested in other species. |
| Packaging: | | 0.1 mg Immunogen affinity purified Goat antisera. |
| Uses: | | This antibody can be used for ELISA and Western Blot. In Western Blot, approx 100kDa band observed in Human epidermoid carcinoma A431 lysates (calculated MW of 100kDa according to NP_002799). Not tested in other applications.Recommended Starting Dilution:*ELISA (peptide): 1:16,000WB: 0.03-0.3ug/ml*Optimal dilutions should be determined by the end user. |
| Background: | | The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. 26S S2 is one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1 |
| Storage: | | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | | Immunogen affinity purified |
| Isotype: | | IgG |
| Host_Name: | | Goat |
| Buffer: | | Tris-saline containing 0.02% Na azide [pH7.3] with 0.5% BSA |
| ListPrice: | | 295 |
| AppSummary: | | ELISA, WB |
| SpeciesSummary: | | Hu |
| ALTnames: | | anti-26S proteasome non-ATPase regulatory subunit 2 antibody, anti-26S proteasome regulatory subunit RPN1 antibody, anti-26S proteasome regulatory subunit S2 antibody, anti-26S proteasome subunit p97 antibody, anti-55.11 protein antibody, anti-PSMD2 antibody, anti-TRAP2 Tumor necrosis factor type 1 receptor associated protein 2 antibody |
| ProteinTarget: | | Proteasome 26S S2 |
| PackageSize: | | 0.1 mg |
| GeneralRef: | | Store at +4 degrees C short term. Aliquot and store at -20 degrees C or -80 degrees C. Avoid repeated freeze / thaw cycles. |
| Gene_Id: | | 5708 |
| Omim_ID: | | NB120-3333 |
| more information: | | company product webpage |