| CatalogCode: | NB100-1402 |
| ProductName: | MDC1 Antibody |
| Product Description: | Goat Polyclonal anti-MDC1 |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic Peptide C-EAFVLSPLEMSST, representing the C-Terminus of the human protein according to NP_055456. |
| CrossReactivity: | Expected from sequence similarity: Human |
| Packaging: | Immunogen affinity purified Goat antisera. |
| Uses: | This antibody can be used for ELISA and Western Blot. In Western Blot, preliminary experiments gave no signal but low background in Human Brain and H460 cell lysates. Not tested in other applications.Recommended Starting Dilution:*ELISA (peptide): 1:4,000WB: 1ug/ml*Optimal dilutions should be determined by the end user. |
| Localization: | nuclear |
| Background: | **Please note, this product is one of a range of Investigative Grade antibodies, made against targets that have limited or no commercial antibodies available to them and for which there are no data on the expression of the protein in the range of common cell lines and tissues available to us. These antibodies are affinity purified using their peptide immunogen and are known to give low background staining in a western blot. However no additional claims are made for their ability to recognize native protein in any application. The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Goat |
| Buffer: | Tris-saline containing 0.02% Na azide [pH7.3] with 0.5% BSA |
| ListPrice: | 195 |
| AppSummary: | ELISA, WB |
| SpeciesSummary: | Hu |
| ALTnames: | anti-MDC1 antibody, anti-NFBD1 antibody, anti-NFBD-1 antibody, anti-Mediator of DNA Damage Checkpoint Protein 1 antibody, anti-nuclear factor with BRCT domains protein 1 antibody, anti-KIAA antibody |
| ProteinTarget: | Goat Anti-MDC1 / NFBD1 |
| NotesMain: | **Please note, this product is one of a range of Investigative Grade antibodies, made against targets that have limited or no commercial antibodies available to them and for which there are no data on the expression of the protein in the range of common cell lines and tissues available to us. These antibodies are affinity purified using their peptide immunogen and are known to give low background staining in a western blot. However no additional claims are made for their ability to recognise native protein in any application. |
| Gene_Id: | 9656 |
| Omim_ID: | NB100-2604 |
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