| CatalogCode: | NB100-1300 |
| ProductName: | FBXW2 Antibody |
| Product Description: | Goat Polyclonal anti-FBXW2 |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide: KRGSSFLAGEHPG representing the C-Terminus of the human protein (residues 410-422), according to NP_036296. |
| CrossReactivity: | Cross-reacts with Human. Not yet tested in other species. |
| Packaging: | 0.1 mg Immunogen affinity purified Goat antisera. |
| Uses: | This antibody can be used for ELISA and Western Blot. In Western Blot, preliminary experiments gave no signal but low background in Human Kidney and Testis lysates. This antibody has also been used for immunohistochemistry. Not tested in other applications.Recommended Starting Dilution:*ELISA (peptide): 1/32000WB: 1ug/ml*Optimal dilutions/concentrations should be determined by the end user. |
| Background: | F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. A large family of mammalian F-box proteins has recently been identified and classified into three groups based on the presence of either the WD-40 repeats, the leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. The FBXW2 gene product, the second identified member of the F-box gene family, contains multiple WD-40 repeats. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Goat |
| Buffer: | Tris saline containing [pH7.3] with 0.5% BSA |
| ListPrice: | 295 |
| AppSummary: | ELISA, IHC, WB, IHC-P |
| SpeciesSummary: | Hu |
| ALTnames: | anti-F Box and WD40 Domain Protein 2 antibody, anti-FBW 2 antibody, anti-FBW2 antibody, anti-FBXW 2 antibody |
| ProteinTarget: | FBXW2 |
| PackageSize: | 0.1 mg |
| GeneralRef: | Winston JT et al. A family of mammalian F-box proteins. Curr Biol 9:1180-2 (1999). |
| Gene_Id: | 26190 |
| Omim_ID: | H00006468-A01 |
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