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| Catalog Code: | NB100-129 |
| Product Name: | BMAL Antibody |
| Product Description: | Rabbit Polyclonal anti-BMAL |
| Clonality: | Polyclonal |
| ListPrice: | 285 |
| Immunogen: | Bacterially expressed human MOP3 |
| Specificity: | This antibody is specific for MOP3/BMAL1. |
| Cross Reactivity: | Recognizes human MOP3. Other species have not been tested. |
| Packaging: | 0.4 ml rabbit antisera with sodium azide. |
| Uses: | May be used in Western analysis where it recognizes a band at ~73 kDa representing BMAL1.Also works for ChIP Assay (request specific protocol if needed). |
| Background: | MOP3 (BMAL1), a general dimerization partner for a subset of the bHLH-PAS (basic-helix-loop-helix-PER-ARNT-SIM) superfamily of transcription regulators, is involved in circadian rhythm generation. MOP3 interacts with MOP4, CLOCK, Hypoxia-inducible factor-1 alpha and -2 alpha. This interaction appears to be distinct from that of the more characterized general partner, ARNT (HIF-1Beta). |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Whole antisera |
| Host Name: | Rabbit |
| Application Summary: | Western Blot 1:100-1:200 , 5 ul of reticulocyte lysate translated hMOP3 protein incubated for 2 hours at RT. Sensitivity may be increased by incubating overnight at 4 degrees C. |
| Species Summary: | Hu |
| Alternate Names: | Anti-ARNTL antibody; Anti-Aryl hydrocarbon receptor nuclear translocator like antibody, Anti-Basic helix loop helix PAS orphan MOP3 antibody, Anti-bHLH PAS protein JAP3 antibody, Anti-BMAL 1 antibody, Anti-BMAL1 antibody, Anti-Brain and muscle ARNT like 1 antibody, Anti-Member of PAS protein 3 antibody, Anti-MOP 3 antibody, Anti-PASD3 antibody, Anti-TIC antibody, anti-BMAL antibody |
| Package Size: | 0.4 ml |
| General References: | 1. Hogenesch, J., et al. The basic-helix-lop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors. Proc. Natl. Acad. Sci. USA. 95: 5474-5479, 1998. 2. Gekakis, N., et al. Role of the CLOCK protein in the mammalian circadian mechanism. Science. 280: 1564-1569, 1998. 3. Oishi, K., et al. Antiphase Circadian Expression between BMAL1 and period Homologue mRNA in the Suprachiasmatic Nucleus and Peripheral Tissues of Rats. Biochemical and Biophysical Research Communications. 253: 199-203, 1998. 4. Bunger, M.K. et al. Mop3 is an Essential Component of the Master Circadian Pacemaker in Mammals. Cell. 103: 1009-1017, 2000. |
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