| CatalogCode: | | NB100-127 |
| ProductName: | | ARA9 Antibody |
| Product Description: | | Mouse Monoclonal anti-ARA9 (35-2) |
| Clone: | | 35-2 |
| Clonality: | | Monoclonal |
| Immunogen: | | Bacterially expressed human ARA9. |
| Epitope: | | Expected to be between amino acids 305-330. |
| Specificity: | | This antibody is specific for ARA9. |
| CrossReactivity: | | Human and mouse. Other species have not been tested. |
| Packaging: | | 0.1 ml Tissue culture supernatant Mouse ascites. |
| Uses: | | This antibody may be used for Western blotting where a band is seen at 37 kDa, representing ARA9. It is specific for the FKBP domain. |
| Localization: | | Cytoplasmic |
| Background: | | Ah receptor-associated protein (ARA9) is also known as AIP and XAP2. This protein displays structural similarity to the glucocorticoid receptor-associated immunophilin FKBP52. Although they share significant homology, they have distinct cellular roles and biochemical properties. ARA9 is known to affect the potency and efficacy of AHR agonists in the yeast Saccharomyces cerevisiae as well as having functional consequence on AHR signal transduction. |
| Storage: | | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | | Tissue culture supernatant |
| Isotype: | | IgG1 |
| Host_Name: | | Mouse |
| ListPrice: | | 285 |
| NovusRef: | | [References for Clone 35-2 ascites] 1. Petrulis, John R., et al. Subcellular Localization of the Aryl Hydrocarbon Receptor is Modulated by the Immunophilin Homolog Hepatitis B Virus X-associated Protein 2*. The Journal of Biological Chemistry. 275(48):37448-37453, 2000. 2. Hollingshead, B., et al. The Aryl Hydrocarbon (Ah) Receptor Transcriptional Regulator Hepatitis B Virus X-associated Protein 2 Antagonizes and Is Dispensable for Receptor Function. J. Biol. Chem. 279: 45652-45661, 2004. 2. Pollenz, R. S., Wilson, S. E., and Dougherty, E. J. (2006) Role of Endogenous XAP2 Protein on the Localization and Nucleocytoplasmic Shuttling of the Endogenous Mouse Ahb-1 Receptor in the Presence and Absence of Ligand, 70, 1369-1379. |
| AppSummary: | | IP, WB |
| SpeciesSummary: | | Hu, Mu |
| ALTnames: | | anti-AIP antibody; anti-Aryl Hydrocarbon Receptor Interacting Protein antibody; anti-FKBP37 antibody; anti-HBVX Associated Protein antibody; anti-XAP2 antibody; anti-Ara-9 antibody |
| ProteinTarget: | | ARA9 |
| PackageSize: | | 0.1 ml |
| GeneralRef: | | 1. Carver, Lucy A., et al. Characterization of the Ah Receptor-associated Protein, ARA9. The Journal of Biological Chemistry. 273(50): 33580-33587, 1998. 2. Carver, Lucy A., and Bradfield, Christopher A. Ligand-dependent Interaction of the Aryl Hydrocarbon Receptor with a Novel Immunophilin Homolog in Vivo. The Journal of Biological Chemistry. 272(17): 11452-11456, 1997. |
| more information: | | company product webpage |