| CatalogCode: | | NB100-1175 |
| ProductName: | | RNF7 Antibody |
| Product Description: | | Goat Polyclonal anti-RNF7 |
| Clonality: | | Polyclonal |
| Immunogen: | | Synthetic Peptide CQQDWVVQRIGK, representing the C-Terminus of the human protein (residues 102-113), according to NP_055060 |
| CrossReactivity: | | Expected to cross-react with Human and Mouse due to sequence homology. Not yet tested in other species. |
| Packaging: | | 0.1 mg Immunogen affinity purified Goat antisera. |
| Uses: | | This antibody can be used for ELISA and Western Blot. In Western Blot, no signal obtained yet but low background observed in Human Heart and Human Testis lysates. Not tested in other applications.Recommended Starting Dilution:*ELISA (peptide): 1:16000)WB: 1.0ug/ml*Optimal dilutions should be determined by the end user. |
| Background: | | **Please note, this product is one of a range of Investigative Grade antibodies, made against targets that have limited or no commercial antibodies available to them and for which there are no data on the expression of the protein in the range of common cell lines and tissues available to us. These antibodies are affinity purified using their peptide immunogen and are known to give low background staining in a western blot. However no additional claims are made for their ability to recognize native protein in any application. The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported. |
| Storage: | | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | | Immunogen affinity purified |
| Isotype: | | IgG |
| Host_Name: | | Goat |
| Buffer: | | Tris saline containing [pH7.3] with 0.5% BSA |
| ListPrice: | | 195 |
| AppSummary: | | ELISA, WB |
| SpeciesSummary: | | Hu |
| ALTnames: | | anti-CKBBP1 antibody, anti-CKII Beta Binding Protein 1 antibody, anti-Rbx2 antibody, anti-Regulator Of Cullins 2 antibody, anti-Ring Finger Protein 7 antibody, anti-SAG antibody, anti-Sensitive To Apoptosis Gene antibody |
| ProteinTarget: | | RNF 7 |
| PackageSize: | | 0.1 mg |
| GeneralRef: | | Duan H et al. SAG, a novel zinc RING finger protein that protects cells from apoptosis induced by redox agents. Mol Cell Biol 19:3145-55 (1999). |
| NotesMain: | | **Please note, this product is one of a range of Investigative Grade antibodies, made against targets that have limited or no commercial antibodies available to them and for which there are no data on the expression of the protein in the range of common cell lines and tissues available to us. These antibodies are affinity purified using their peptide immunogen and are known to give low background staining in a western blot. However no additional claims are made for their ability to recognise native protein in any application. |
| Gene_Id: | | 9616 |
| Omim_ID: | | H00009025-B01 |
| more information: | | company product webpage |