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| Catalog Code: | NB100-1144 |
| Product Name: | CIAS 1 Antibody |
| Product Description: | Goat Polyclonal anti-CIAS 1 |
| Clonality: | Polyclonal |
| ListPrice: | 195 |
| Gene ID: | 114548 |
| Concentration: | 0.5 mg/ml |
| Immunogen: | Synthetic Peptide EKPELTVVFEPSW, representing the C-Terminus of the human protein (1024-1036), according to NP_004886. |
| Cross Reactivity: | Expected to cross-react with Human and Rat due to sequence homology. Not yet tested in other species. |
| Packaging: | 0.1 mg Immunogen affinity purified Goat antisera. |
| Uses: | This antibody can be used for ELISA and Western Blot. In Western Blot, no signal obtained yet but low background observed in Daudi, A431, Jurkat, U937 and MOLT 4 lysates.Not tested in other applications.Recommended Starting Dilution:*ELISA (peptide): 1/32000WB: 1.0 ug/ml*Optimal dilutions should be determined by the end user. |
| Background: | **Please note, this product is one of a range of Investigative Grade antibodies, made against targets that have limited or no commercial antibodies available to them and for which there are no data on the expression of the protein in the range of common cell lines and tissues available to us. These antibodies are affinity purified using their peptide immunogen and are known to give low background staining in a western blot. However no additional claims are made for their ability to recognize native protein in any application. This gene encodes a pyrin-like protein which contains a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with apoptosis-associated speck-like protein containing a CARD. Proteins which contain the caspase recruitment domain, CARD, have been shown to be involved in inflammation and immune response. This protein may function as an activator of NF-kappaB signaling. The encoded protein may play a role in the regulation of inflammation and apoptosis. Mutations in this gene have been associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Goat |
| Buffer: | Tris saline containing [pH7.3] with 0.5% BSA |
| Application Summary: | ELISA, Western Blot |
| Species Summary: | Hu, Rt, |
| Package Size: | 0.1 mg |
| Preservative: | 0.02% Na azide |
| Notes Main: | **Please note, this product is one of a range of Investigative Grade antibodies, made against targets that have limited or no commercial antibodies available to them and for which there are no data on the expression of the protein in the range of common cell lines and tissues available to us. These antibodies are affinity purified using their peptide immunogen and are known to give low background staining in a western blot. However no additional claims are made for their ability to recognise native protein in any application. |
| General References: | Hoffman HM et al. Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome. Nat Genet 29:301-5 (2001). |
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