| CatalogCode: | NB100-1143 |
| ProductName: | ERp57 Antibody |
| Product Description: | Goat Polyclonal anti-ERp57 |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide: EEKPKKKKKAQEDL, representing the C-terminus of the human protein (residues 492-505), according to NP_005304. |
| CrossReactivity: | Cross-reacts with Human. Expected to cross-react with Mouse, Rat, Rabbit and Hamster due to sequence homology. Not yet tested in other species. |
| Packaging: | 0.1 mg Immunogen affinity purified Goat antisera. |
| Uses: | This antibody can be used for ELISA and Western Blot. In Western Blot, detects a band of approximately 60 kDa (predicted molecular weight: 58 kDa) from A549 lysates. Not tested in other applications.Recommended Starting Dilution:*ELISA: 1/8000WB: 1 - 3 ug/ml*Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Endoplasmic reticulum |
| Control: | A549 lysate |
| Background: | ERp57, also known as GRP58, was cloned by three independent labs, all of which reported that the gene encodes a 505-amino acid protein that shares significant homology with the molecular chaperone protein disulfide isomerase (PDI). The ERp57 sequence was also shown to include a putative nuclear localization motif and an endoplasmic reticulum (ER) retention motif. Studies have shown that ERp57 functions together with calnexin and calreticulin as a molecular chaperone of glycoprotein biosynthesis within the ER. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Goat |
| Buffer: | Tris saline containing [pH7.3] with 0.5% BSA |
| ListPrice: | 295 |
| AppSummary: | ELISA, WB |
| SpeciesSummary: | Hu |
| ALTnames: | anti-Disulfide isomerase ER 60 antibody, anti-ERp60 antibody, anti-ERp61 antibody, anti-Glucose Regulated Protein 58 Kd antibody, anti-GRP57 antibody, anti-GRP58 antibody, anti-Phospholipase C alpha antibody, anti-PI PLC antibody |
| ProteinTarget: | ERp57 |
| PackageSize: | 0.1 mg |
| GeneralRef: | Koivunen P et al. Structures of the human gene for the protein disulfide isomerase-related polypeptide ERp60 and a processed gene and assignment of these genes to 15q15 and 1q21. Genomics 42:397-404 (1997). |
| Gene_Id: | 2923 |
| Omim_ID: | NB120-13507 |