| Catalog Code: | NB100-104 |
| Product Type: | Primary Antibody |
| Product Name: | ATM Antibody |
| List Price: | 275 |
| Clonality: | Polyclonal |
| Gene ID: | 472 |
| Host: | Rabbit |
| Product Description: | Rabbit Polyclonal anti-ATM |
| Cross Reactivity: | Human. Other species have not been tested. |
| Species Summary: | Hu |
| Background: | Ataxia-telangiectasia (A-T) is a recessive childhood disease caused by mutations in the ATM (AT-mutated) gene. Symptoms include neurological abnormalities that cause unsteady posture, dilated blood vessels, infertility, radiation sensitivity, immune defi |
| Alternate Names: | anti-AT complementation group A antibody, anti-AT complementation group C antibody, anti-AT complementation group D antibody, anti-AT complementation group E antibody, anti-AT mutated protein antibody, anti-AT1 antibody, anti-ATA antibody, anti-Ataxia tel |
| Immunogen: | A fragment of human ATM protein expressed in E.coli. The fragment relates to the C-terminal region (within the last third of the protein sequence). |
| Localization: | Nuclear |
| Specificity: | This antibody is specific for ATM. |
| Purity: | Affinity purified |
| Buffer: | PBS with 50% glycerol |
| Packaging: | 0.05 ml of affinity purified rabbit sera. |
| Package Size: | 0.05 ml |
| Concentration: | 0.5 mg/ml |
| Uses: | NB 100-104 can be used in Western blot where it detects a band at 350 kDa, representing ATM. It is also useful for immunoprecipitation and immunofluorescence. NB 100-104 has also been used in protein kinase assays. |
| Application Summary: | IHC, IP, WB |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| General References: | Rogoff, H., et al. Apoptosis Associated with Derefulated E2F Activity Is Dependent on E2F1 and Atm/Nbs1/Chk2. Mol. and Cell. Biol. 24(7): 2968-2977 (2004) |
| Product References: | 1. Out, R., et al. Adenovirus-mediated hepatic overexpression of scavenger receptor class B tyoe I accelerates chylomicron metabolism in C57BL/6J mice. J. Lipid Res. 46: 1172-1181 (2005) [Western blot, Mouse] 2. Cuadrado, M., et al. ATM regulates ATR chro |
| Novus References: | 1. Wang, et al. BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. Genes & Dev. 14: 927-939 (2000) [Western Blot, Immunohistochemistry, Immunoprecipitation, Immunofluorescense, Human |