| CatalogCode: | | NB100-1032 |
| ProductName: | | DAP3 Antibody |
| Product Description: | | Goat Polyclonal anti-DAP3 |
| Clonality: | | Polyclonal |
| Immunogen: | | Synthetic peptide NPSLLERHCAYL, representing the C-Terminus of the human protein (residues 387-398), according to NP_004623; NP_387506 |
| Specificity: | | This antibody is expected to recognise both human isoforms of this protein. |
| CrossReactivity: | | Cross-reacts with Human. Not yet tested in other species. |
| Packaging: | | 0.1 mg Immunogen affinity purified Goat antisera. |
| Uses: | | This antibody can be used for Western Blot - ? Approx 40-45kDa band seen in HeLa lysate.Not tested in other applications.Recommended Starting Dilution:*WB: 2.0-4.0ug/ml*Optimal dilutions should be determined by the end user. |
| Localization: | | Mitochondrial |
| Background: | | Death Associated Protein 3 (DAP3) is a 46 kDa protein carrying a potential nucleotide binding motif (P-loop) at its N-terminal region. The protein is widely expressed, and the expression is upregulated during membrane-receptor mediated apoptosis. In interferon-gamma and Fas induced apoptosis, DAP3 acts as a positive mediator by functioning downstream of the receptor signaling complex and upstream of the effector caspases. However, the mechanism for its function is largely unknown. Interestingly, the N-terminal 230 amino acid fragment of DAP3 alone protects cells from Fas induced cell death. The same region of DAP3 also serves as a binding site for the glucocorticoid receptor and mediates receptor functions. |
| Storage: | | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | | Immunogen affinity purified |
| Isotype: | | IgG |
| Host_Name: | | Goat |
| Buffer: | | Tris saline containing [pH7.3] with 0.5% BSA |
| ListPrice: | | 295 |
| AppSummary: | | WB |
| SpeciesSummary: | | Hu |
| ALTnames: | | anti-DAP-3 antibody, anti-DKFZp686G12159 antibody, anti-MRP-S29 antibody, anti-MRPS29 antibody, anti-bMRP-10 antibody |
| ProteinTarget: | | DAP 3 |
| PackageSize: | | 0.1 mg |
| GeneralRef: | | Kissil JL et al. Isolation of DAP3, a novel mediator of interferon-gamma-induced cell death. J Biol Chem 270:27932-6 (1995). |
| Gene_Id: | | 7818 |
| Omim_ID: | | NB100-56539 |
| more information: | | company product webpage |