| CatalogCode: | NB100-1005 |
| ProductName: | NQO1 Antibody |
| Product Description: | Goat Polyclonal anti-NQO1 |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide C-SIPTDNQIKARK, representing the C-Terminus of the human protein (residues 267-274), according to NP_000894 |
| CrossReactivity: | Tested: Human Expected from sequence similarity: Mouse, Rat |
| Packaging: | 0.1 mg Immunogen affinity purified Goat antisera. |
| Uses: | Peptide ELISA: antibody detection limit dilution 1:2,000. Western Blot: Approx 28kDa band observed in Human Lung lysates (calculated MW of 30.9kDa, 27.3, 26.4 according to NP_000894.1, NP_001020604.1and NP_001020605.1 resp.). Recommended concentration: 1-3ug/ml. |
| Background: | NQO1 is a 2-electron reductase that detoxifies quinones derived from the oxidation of phenolic metabolites of benzene. Individuals homozygous for the T/T form of the 609C-T polymorphism have an increased risk of benzene hematotoxicity. Principal Names NQO1; NAD(P)H dehydrogenase, quinone 1; DTD; QR1; DHQU; DIA4; NMOR1; NMORI; diaphorase-4; diaphorase (NADH/NADPH); diaphorase (NADH/NADPH) (cytochrome b-5 reductase); NAD(P)H:menadione oxidoreductase 1, dioxin-inducible 1.Official Gene Symbol - NQO1.GenBank Accession Number ? NP_000894.LocusLink ID - 1728.Gene Ontology terms - cytoplasm; xenobiotic metabolism; detoxification response; cytochrome b5 reductase; nitric oxide biosynthesis; NAD(P)H dehydrogenase (quinone); synaptic transmission, cholinergic. |
| ProductRef: | 1. Singh, S., Zahid, M., Gaikwad, N., Chakravarti, D., Cavalieri, E. L., and Rogan, E. G. (2006) The effect of NAD(P)H:quinone oxidoreductase 1 polymorphisms on estrogen metabolism in relation to initiation of breast cancer, 2006, 835-b-. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Goat |
| Buffer: | Tris saline containing [pH7.3] with 0.5% BSA |
| ListPrice: | 295 |
| AppSummary: | ELISA, WB |
| SpeciesSummary: | Hu |
| ALTnames: | anti-DHQU antibody, anti-DIA4 antibody, anti-Diaphorase (NADH/NADPH) (cytochrome b-5 reductase) antibody, anti-Diaphorase (NADH/NADPH) antibody, anti-Diaphorase 4 antibody, anti-DTD antibody, anti-NAD(P)H dehydrogenase quinone 1 antibody, anti-NAD(P)H: menadione oxidoreductase 1 dioxin inducible 1 antibody, anti-NMOR1 antibody, anti-NMORI antibody, anti-QR1 antibody |
| ProteinTarget: | NQO1 |
| PackageSize: | 0.1 mg |
| GeneralRef: | Asher G et al. NQO1 stabilizes p53 through a distinct pathway. Proc Natl Acad Sci U S A 99:3099-104 (2002). |
| Gene_Id: | 1728 |
| Omim_ID: | NB200-209SS |
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