| CatalogCode: | | H00140885-M10 |
| ProductName: | | protein tyrosine phosphatase Antibody |
| Product Description: | | Mouse Monoclonal anti-protein tyrosine phosphatase (4C7) |
| Clone: | | 4C7 |
| Clonality: | | Monoclonal |
| Immunogen: | | PTPNS1 (AAH26692, 28 a.a. ~ 508 a.a) full length recombinant protein with GST tag. |
| Epitope: | | VAGEEELQVIQPDKSVSVAAGESAILHCTVTSLIPVGPIQWFRGAGPARELIYNQKEGHFPRVTTVSESTKRENMDFSISISNITPADAGTYYCVKFRKGSPDTEFKSGAGTELSVRAKPSAPVVSGPAARATPQHTVSFTCESHGFSPRDITLKWFKNGNELSDFQTNVDPVGESVSYSIHSTAKVVLTREDVHSQVICEVAHVTLQGDPLRGTANLSETIRVPPTLEVTQQPVRAENQVNVTCQVRKFYPQRL ... |
| Specificity: | | protein tyrosine phosphatase, non-receptor type substrate 1 |
| CrossReactivity: | | Human. Other species not tested. |
| Packaging: | | 0.1 mg IgG purified Mouse ascites. |
| Uses: | | Antibody Reactive against Recombinant Protein with GST tag on ELISA and Western Blot. GST tag alone is used as a negative control. The antibody is also shown to be specific in Western blot against cell lysates. |
| Background: | | The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. |
| Storage: | | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | | IgG purified |
| Isotype: | | IgG2a Kappa |
| Host_Name: | | Mouse |
| Buffer: | | 1X PBS pH 7.2 |
| ListPrice: | | 295 |
| AppSummary: | | ELISA, WB |
| SpeciesSummary: | | Hu |
| ALTnames: | | anti-BIT antibody, anti-CD172A antibody, anti-MFR antibody, anti-MYD-1 antibody, anti-P84 antibody, anti-SHPS-1 antibody, anti-SHPS1 antibody, anti-SIRP antibody, anti-SIRP-ALPHA-1 antibody, anti-SIRPalpha antibody, anti-SIRPalpha2 antibody |
| ProteinTarget: | | protein tyrosine phosphatase, non-receptor type substrate 1 |
| PackageSize: | | 0.1 mg |
| NotesMain: | | This antibody is available only in North America and is supplied by Abnova If in stock in Taiwan. delivery is 10-14 days. If not in stock. lead times can be extended. We will inform you of any extended delays within 48 hours. The immunizing protein is also available for this product. Unit cost for the protein is $ 250 (2 ug). $ 305 (10 ug). and $ 445 (25 ug). |
| Gene_Id: | | 140885 |
| Gene_Symbol: | | PTPNS1 |
| Omim_ID: | | 602461, |
| more information: | | company product webpage |