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| Catalog Code: | H00009232-M11 |
| Product Name: | PTTG1 Antibody |
| Product Description: | Mouse Monoclonal anti-PTTG1 - pituitary tumor-transforming 1 (3F9) |
| Clone: | 3F9 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Gene ID: | 9232 |
| Gene Symbol: | PTTG1 |
| Immunogen: | PTTG1 (NP_004210, 0 a.a. ~ 0 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Cross Reactivity: | Human. |
| Packaging: | 0.1 mg IgG purified Mouse ascites. |
| Uses: | Antibody Reactive Against Recombinant Protein with GST tag on ELISA and Western Blot. GST tag alone is used as a negative control. |
| Background: | The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | IgG purified |
| Isotype: | IgG2a Kappa |
| Host Name: | Mouse |
| Buffer: | In 1x PBS, pH 7.2 |
| Application Summary: | ELISA, Western Blot |
| Species Summary: | Hu |
| Alternate Names: | anti-EAP1 antibody, anti-HPTTG antibody, anti-MGC126883 antibody, anti-MGC138276 antibody, anti-PTTG antibody, anti-SECURIN antibody, anti-TUTR1 antibody |
| Package Size: | 0.1 mg |
| Preservative: | No Preservative |
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