| CatalogCode: | H00006786-M01 |
| ProductName: | STIM1 Antibody |
| Product Description: | Mouse Monoclonal anti-STIM1 (5A2) |
| Clone: | 5A2 |
| Clonality: | Monoclonal |
| Immunogen: | Recombinant full length human protein with GST tag, between amino acids 24-686 [NCBI#AAH21300]. |
| Epitope: | SHSHSEKATGTSSGANSEESTAAEFCRIDKPLCHSEDEKLSFEAVRNIHKLMDDDANGDVDVEESDEFLREDLNYHDPTVKHSTFHGEDKLISVEDLWKAWKSSEVYNWTVDEVVQWLITYVELPQYEETFRKLQLSGHAMPRLAVTNTTMTGTVLKMTDRSHRQKLQLKALDTVLFGPPLLTRHNHLKDFMLVVSIVIGVGGCWFAYIQNRYSKEHMKKMMKDLEGLHRAEQSLHDLQERLHKAQEEHRTVEVE ... |
| CrossReactivity: | Human. Other species have not been tested. |
| Packaging: | 0.1 mg IgG purified Mouse ascites. |
| Uses: | Antibody Reactive against Recombinant Protein with GST tag on ELISA and Western Blot. GST tag alone is used as a negative control. The antibody is also shown to be specific in Western blot against cell lysates. It has also been used in immunohistochemistry on paraffin-embedded sections. |
| Background: | This gene encodes a type 1 transmembrane protein of unknown function. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene. |
| ProductRef: | 1. Pani B, Ong HL, Liu X, Rauser K, Ambudkar IS, Singh BB. Lipid rafts determine clustering of STIM1 in ER-plasma membrane junctions and regulation of SOCE. J Biol Chem. 2008 Apr 22. 2. Alicia S, Angelica Z, Carlos S, Alfonso S, Luis V. STIM1 converts TRPC1 from a receptor-operated to a store-operated channel: Moving TRPC1 in and out of lipid rafts. Cell Calcium. 2008 Apr 15. 3. Grosse J, Braun A, Varga-Szabo D, et al. An EF hand mutation in Stim1 causes premature platelet activation and bleeding in mice. J Clin Invest. 2007 Nov 1;117(11):3540-3550. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | IgG purified |
| Isotype: | IgG2a kappa |
| Host_Name: | Mouse |
| Buffer: | PBS, [pH7.2] |
| ListPrice: | 295 |
| NovusRef: | 1. Prakash,Y.S., et al. Caveolins and intracellular calcium regulation in human airway smooth muscle. Am. J. Physiol. Lung Cell Mol. Physiol. 293: L1118-L1126 (2007). |
| AppSummary: | ELISA, WB, IHC-P |
| SpeciesSummary: | Hu |
| ALTnames: | anti-Stromal interaction molecule 1 antibody, anti-D11S4896E antibody, anti-GOK antibody |
| ProteinTarget: | STIM1 - stromal interaction molecule 1 |
| PackageSize: | 0.1 mg |
| NotesMain: | This antibody is available only in North America and is supplied by Abnova If in stock in Taiwan. delivery is 10-14 days. If not in stock. lead times can be extended. We will inform you of any extended delays within 48 hours. The immunizing protein is also available for this product. Unit cost for the protein is $ 250 (2 ug). $ 305 (10 ug). and $ 445 (25 ug). |
| Gene_Id: | 6786 |
| Gene_Symbol: | STIM1 |
| Omim_ID: | 605921 NB110-60547SS |
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