| request information: |
|
| Catalog Code: | H00006446-M02 |
| Product Name: | SGK Antibody |
| Product Description: | Mouse Monoclonal anti-SGK (3E3) |
| Clone: | 3E3 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Gene ID: | 6446 |
| Gene Symbol: | SGK |
| Omim ID: | 602958, |
| Immunogen: | SGK (AAH01263, 1 a.a. ~ 91 a.a) partial recombinant protein with GST tag. |
| Epitope: | MTVKTEAAKGTLTYSRMRGMVAILIAFMKQRRMGLNDFIQKI ANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQIN LGPSSN* |
| Specificity: | SGK - serum/glucocorticoid regulated kinase |
| Cross Reactivity: | Human. Other species not tested. |
| Packaging: | 0.1 mg IgG purified Mouse ascites. |
| Uses: | Antibody reactive against recombinant protein for Western Blot. Has also been used for immunohistochemistry (paraffin) and ELISA. |
| Localization: | Cytoplasmic and Nuclear (on phosphorylation). |
| Background: | This gene encodes a serine/threonine protein kinase that is highly similar to the rat serum-and glucocorticoid-induced protein kinase (SGK). This gene was identified in a screen of hepatocellular genes regulated in response to cellular hydration or swelling. Cellular hydration is a catabolic signal, stimulating glycogenolysis and proteolysis, and inhibiting protein and glycogen synthesis. This kinase has been shown to be important in activating certain potassium, sodium, and chloride channels. Expression of this gene in hepatocytes is stimulated by transforming growth factor-beta (TGF-beta) which participates in the pathophysiology of diabetic complications. Since both TGF-beta expression and SGK expression are elevated in diabetic nephropathy, this suggests an involvement of SGK in the development of this condition. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | IgG purified |
| Isotype: | IgG2b Kappa |
| Host Name: | Mouse |
| Buffer: | Phosphate buffered saline, pH 7.2 |
| Application Summary: | ELISA, Immunohistochemistry-Paraffin, Western Blot |
| Species Summary: | Hu |
| Alternate Names: | anti-SGK1 antibody, anti-Serum/glucocorticoid regulated kinase 1 antibody, anti-Serine/threonine protein kinase SGK antibody, anti-Serine/threonine protein kinase Sgk1 antibody, anti-Serum and glucocorticoid regulated kinase antibody, anti-Serum/glucocorticoid regulated kinase antibody, anti-SGK 1 antibody, anti-SGK antibody |
| Package Size: | 0.1 mg |
| Preservative: | No preservative |
order or
more information: | company product webpage |