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| Catalog Code: | H00005728-M02 |
| Product Name: | PTEN Antibody |
| Product Description: | Mouse Monoclonal anti-PTEN (3E7) |
| Clone: | 3E7 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Gene ID: | 5728 |
| Gene Symbol: | PTEN |
| Omim ID: | 137800, 153480, 158350, 176807, 176920, 188470, 276950, 601728, 607174, |
| Immunogen: | PTEN (NP_000305, 2 a.a. ~ 91 a.a) full-length recombinant protein with GST tag. |
| Cross Reactivity: | Human. Other species not tested. |
| Packaging: | 0.1 mg IgG purified Mouse ascites. |
| Uses: | Antibody reactive against cell lysate and recombinant protein for western blot. It has also been used for ELISA. |
| Background: | This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | IgG purified |
| Isotype: | IgG2a Kappa |
| Host Name: | Mouse |
| Buffer: | In 1x PBS, pH 7.2 |
| Application Summary: | ELISA, Western Blot |
| Species Summary: | Hu |
| Alternate Names: | anti-BZS antibody, anti-MGC11227 antibody, anti-MHAM antibody, anti-MMAC1 antibody, anti-PTEN1 antibody, anti-TEP1 antibody |
| Package Size: | 0.1 mg |
| Preservative: | No Preservative |
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more information: | company product webpage |
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