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| Catalog Code: | H00005727-M10 |
| Product Name: | PTCH Antibody |
| Product Description: | Mouse Monoclonal anti-PTCH (3B3) |
| Clone: | 3B3 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Gene ID: | 5727 |
| Gene Symbol: | PTCH |
| Omim ID: | 109400, 601309, 605462, |
| Immunogen: | PTCH (NP_000255, 651 a.a. ~ 750 a.a) full length recombinant protein with GST tag. |
| Epitope: | AHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVTVTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTK
WTLSSFAEKHYAPFLLKPKAK* |
| Cross Reactivity: | Human. Other species not tested. |
| Packaging: | 0.1 mg IgG purified Mouse ascites. |
| Uses: | Antibody reactive against cell lysate and recombinant protein for western blot. It has also been used for ELISA. |
| Background: | This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | IgG purified |
| Isotype: | IgG2a Kappa |
| Host Name: | Mouse |
| Buffer: | In 1x PBS, pH 7.2 |
| Application Summary: | ELISA, Western Blot |
| Species Summary: | Hu |
| Alternate Names: | anti-BCNS antibody, anti-HPE7 antibody, anti-NBCCS antibody, anti-PTC antibody, anti-PTC1 antibody, anti-patched antibody |
| Package Size: | 0.1 mg |
| Preservative: | No Preservative |
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more information: | company product webpage |
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