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| Catalog Code: | H00005721-M01 |
| Product Name: | PSME2 Antibody |
| Product Description: | Mouse Monoclonal anti-PSME2 (3F11-1A3) |
| Clone: | 3F11-1A3 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Gene ID: | 5721 |
| Gene Symbol: | PSME2 |
| Omim ID: | 602161 |
| Immunogen: | PSME2 (AAH19885, 1 a.a. ~ 240 a.a) full length recombinant protein with GST tag. |
| Epitope: | MAKPCGVRLSGEARKQVEVFRQNLFQEAEEFLYRFLPQKIIY LNQLLQEDSLNVADLTSLRAPLDIPIPDPPPKDDEMETDKQE KKEVPKCGFLPGNEKVLSLLALVKPEVWTLKEKCILVITWIQ HLIPKIEDGNDFGVAIQEKVLERVNAVKTKVEAFQTTISKYF SERGDAVAKASKETHVMDYRALVHERDEAAYGELRAMVLDLR AFYAELYHIISSNLEKIVNPKGEEKPSMY* |
| Specificity: | PSME2 - proteasome (prosome, macropain) activator subunit 2 (PA28 beta) |
| Cross Reactivity: | Human. Other species not tested. |
| Packaging: | 0.1 mg IgG purified Mouse ascites. |
| Uses: | Antibody reactive against transfected lysate and recombinant protein for western blot. It has also been used for ELISA. |
| Background: | The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the beta subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three beta and three alpha subunits combine to form a heterohexameric ring. Six pseudogenes have been identified on chromosomes 4, 5, 8, 10 and 13. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | IgG purified |
| Isotype: | IgG1 kappa |
| Host Name: | Mouse |
| Buffer: | Phosphate buffered saline, pH 7.2 |
| Application Summary: | ELISA, Western Blot |
| Species Summary: | Hu |
| Alternate Names: | anti-11S regulator complex beta subunit antibody, anti-11S regulator complex subunit beta antibody, anti-Activator of multicatalytic protease subunit 2 antibody, anti-Cell migration inducing protein 22 antibody, anti-MCP activator 31 kD subunit antibody, anti-PA28 beta antibody, anti-PA28B antibody, anti-PA28beta antibody, anti-Proteasome (prosome macropain) activator subunit 2 (PA28 beta) antibody, anti-Proteasome (prosome macropain) activator subunit 2 antibody, anti-Proteasome activator 28 beta antibody, anti-Proteasome activator 28 subunit beta antibody, anti-Proteasome activator complex subunit 2 antibody, anti-Proteasome activator hPA28 subunit beta antibody, anti-Proteasome activator subunit 2 antibody, anti-PSME 2 antibody, anti-REG beta antibody, anti-REGbeta antibody |
| Package Size: | 0.1 mg |
| Preservative: | No preservative |
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