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| Catalog Code: | H00005663-A01 |
| Product Name: | PSEN1 Antibody |
| Product Description: | Mouse Polyclonal anti-PSEN1 |
| Clonality: | Polyclonal |
| ListPrice: | 225 |
| Gene ID: | 5663 |
| Gene Symbol: | PSEN1 |
| Omim ID: | 104311 172700 600274 607822 |
| Immunogen: | PSEN1 (AAH11729, 280 a.a. ~ 379 a.a) partial recombinant protein with GST tag. |
| Epitope: | PALIYSSTMVWLVNMAEGDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAAVQ
ELSSSILAGEDPEERGVKLGL |
| Specificity: | PSEN1 - presenilin 1 (Alzheimer disease 3) |
| Cross Reactivity: | Human. Other species not tested. |
| Packaging: | 0.05 ml of mouse antisera with 50% glycerol. No preservative. |
| Uses: | The quality control of this antibody is limited to Western blot on the immunizing protein. Abnovas recommended working dilutions for western analysis are as follows:1:500 dilution for ascites1:1000 for purified Ig1:500-1:1000 for polysera |
| Background: | Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Multiple alternatively spliced transcript variants have been identified for this gene, the full-length natures of only some have been determined. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Whole antisera |
| Host Name: | Mouse |
| Application Summary: | ELISA, Western Blot |
| Species Summary: | Hu |
| Alternate Names: | anti-AD3 antibody, anti-FAD antibody, anti-PS1 antibody, anti-S182 antibody |
| Package Size: | 0.05 ml |
| Preservative: | No preservative |
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more information: | company product webpage |