| CatalogCode: | | DP3500 |
| ProductName: | | LYVE-1 Antibody |
| Product Description: | | Rabbit Polyclonal anti-LYVE-1 |
| Clonality: | | Polyclonal |
| Immunogen: | | This antibody was raised against the extracellular domain of human LYVE-1. |
| CrossReactivity: | | This antibody will detect human LYVE-1 on the surface of lymphatic endothelial cells by Immunohistochemistry. It detects a 70 kD LYVE-1 band in Western blotting. This antibody is not reactive with mouse LYVE-1. Other species not tested. |
| Packaging: | | 0.1 mg Rabbit antisera. |
| Uses: | | Immunohistochemistry on frozen sections (6-30 µg/ml). Use heat mediated antigen retrieval when staining paraffin embedded sections. Western blotting (1-2 µg/ml). ELISA (1-15 µg/ml). FACS analysis ( 3-20 µg/ml). Other applications not tested. Optimal dilutions of this antibody are dependent on conditions and should be determined by the user. |
| Background: | | LYVE-1 has been identified as a major receptor for HA (extracellular matrix glycosamino-glycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequenceof LYVE-1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE-1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE-1 molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE-1 is the first lymph-specificHA receptor to be characterized and is a uniquely powerful marker for lymph vessels. |
| Storage: | | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Host_Name: | | Rabbit |
| ListPrice: | | 355 |
| AppSummary: | | FACS, IHC, WB, ELISA |
| SpeciesSummary: | | Hu |
| ALTnames: | | anti-Extracellular link domain containing 1 antibody, anti-HAR antibody, anti-hyaluronic acid receptor antibody, anti-lymphatic vessel endothelial hyaluronan receptor 1 antibody, anti-LYVE-1 antibody, anti-XLKD1 antibody |
| ProteinTarget: | | Human LYVE-1 |
| PackageSize: | | 0.1 mg |
| NotesMain: | | Store the antibody unreconstituted at 4-8 degrees C or reconstituted in aliquots at -20 degrees C. Antigen distribution not listed on web site. |
| more information: | | company product webpage |