| CatalogCode: | | DM3501 |
| ProductName: | | Podoplanin Antibody |
| Product Description: | | Hamster Monoclonal anti-Podoplanin (811) |
| Clone: | | 811 |
| Clonality: | | Monoclonal |
| Specificity: | | This antibody will detect the extracellular domain of Podoplanin on the surface of mouse lymphatic endothelial cells and some epithelial cell types. |
| CrossReactivity: | | Mouse. Does not react with human protein. Other species have not been tested. |
| Packaging: | | 0.1 mg protein G purified Hamster ascites. Lyophilized IgG fraction. Restore in 0.2 ml distilled water. |
| Uses: | | This antibody is useful for immunoprecipitation, immunohistochemistry (frozen and paraffin-embedded sections), and Western blotting. By Western blot a band between 36-40 kDa is seen. |
| Localization: | | Membrane. |
| Background: | | Podoplanin is a well-recognized lymphatic endothelium marker, which can be used to reliably distinguish lymphatic vessels from blood vessels. Podoplanin is a Mr 38,000 membrane mucoprotein that was originally detected on the surface of rat glomerular epithelial cells (podocytes) and was found to be linked to flattening of foot processes that occurs in glomerular diseases. Podoplanin shows features of a membrane mucoprotein with several conserved O-glycosylation sites. Currently, it is of unknown biological function. Because heavily O-glycosylated mucoproteins were identified recently as counterreceptors for selectins that mediate adhesion of inflammatory cells, it is possible that podoplanin plays a similar role in lymphatic endothelia. |
| Storage: | | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | | protein G purified |
| Isotype: | | IgG |
| Host_Name: | | Hamster |
| Buffer: | | PBS |
| ListPrice: | | 455 |
| AppSummary: | | IP, WB, IHC-P, IHC-Fr |
| SpeciesSummary: | | Hu(-), Mu |
| ALTnames: | | anti-Glycoprotein 36 antibody, anti-Gp36 antibody, anti-T1A antibody, anti-T1-alpha antibody, anti-Aggrus antibody, anti-PDPN antibody |
| ProteinTarget: | | Mouse Podoplanin |
| PackageSize: | | 0.1 mg |
| more information: | | company product webpage |
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