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| Catalog Code: | BC110-60478 |
| Product Name: | PKHD1 Antibody |
| Product Description: | Rabbit Polyclonal anti-PKHD1 |
| Clonality: | Polyclonal |
| ListPrice: | 150 |
| Gene ID: | 5314 |
| Concentration: | 0.2 mg/ml |
| Immunogen: | A synthetic peptide derived from the human PKHD1 protein (within residues 450-550). [UniProt# Q8TCZ9] |
| Specificity: | The specificity of this antibody is unknown. |
| Cross Reactivity: | Species reactivity for this antibody has not been determined. |
| Packaging: | 0.1 ml peptide affinity purified Rabbit antisera. |
| Uses: | Optimal working dilutions should be determined by the investigator.Western Blot: Not tested - Projected working range is 1:1,000-1:10,000.Immunoprecipitation: Not tested - Projected working range is 5-20 ug/mg lysate.Immunohisto/cytochemistry: Not tested - Projected working range is 1:100-1:1,000. |
| Localization: | Membrane; single-pass type I membrane. |
| Background: | BOOT CAMP BACKGROUND: We know how important your research is. For this reason Novus Biologicals offers Boot Camp antibodies to accelerate your discovery based research. Boot Camp antibodies are directed to epitopes on proteins of scientific merit to which there is a scarcity of quality antibodies. Boot Camp antibodies have all been proven by ELISA to exhibit high titers to synthetic peptides that represent their cognate epitopes. However, Novus Biologicals issues no guarantee that Boot Camp antibodies will react with the target protein. _____________________________________________ GENERAL BACKGROUND: Fibrocystin is a type I membrane protein that undergoes regulated proteolysis. Many proteolytic cleavages occur on the ectodomain whereas at least one cleavage occurs on the cytoplasmic portion of fibrocystin. The later generates a C-terminal intracellular fragment that localizes to the nucleus. This proteolysis requires activation of protein kinase C (PKC) and release of intracellular calcium. Fibrocystin is expressed in the cilia of the bile duct epithelium and leads to abnormalities in the rubric of the ductal plate malformation. The intracellular C-terminus of Fibrocystin interacts with calcium modulating cyclophilin ligand (CAML), a protein implicated in calcium signaling. Fibrocystin may participate in the mediation of intracellular calcium in the distal nephron in a manner similar to PKD1 and PKD2. Mutations in the PKHD1 gene, which encodes Fibrocystin, result in autosomal recessive polycystic kidney disease (ARPKD), a severe form of polycystic kidney disease characterized by enlarged kidneys and congenital hepatic fibrosis. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | peptide affinity purified |
| Host Name: | Rabbit |
| Buffer: | PBS, 30% glycerol |
| Alternate Names: | anti-polycystic kidney and hepatic disease 1 antibody, anti-ARPKD antibody, anti-DKFZp686C01112 antibody, anti-FCYT antibody, anti-FLJ46150 antibody, anti-TIGM1 antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.1% sodium azide |
| Homology: | 100% homology with human protein. 88% homology with mouse protein. |
| Notes Main: | Customer Reward: We value your feedback and feel you should be rewarded for your hard work. For each conclusively positive result, using a Boot Camp antibody, Novus Biologicals, Inc. will reward you. You can choose between 1 free unit of antibody (up to 0) or a 0 American Express check. For conclusively negative results, you will receive a American Express check. Terms and Conditions: 1. Reported results must be supported by image(s) and detailed protocol emailed to bootcamp@novusbio.com. 2. Novus Biologicals, Inc. retains the right to use images and other data for product support. 3. Data must be submitted to Novus Biologicals, Inc. within one month of receipt of antibody unless provisions are made in advance. |
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