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| Catalog Code: | AF10710 |
| Product Name: | Cathepsin Z Antibody |
| Product Description: | Mouse Monoclonal anti-Cathepsin Z (237-2D10) |
| Clone: | 237-2D10 |
| Clonality: | Monoclonal |
| ListPrice: | 495 |
| Concentration: | 0.5 mg/ml |
| Immunogen: | Purified mouse monoclonal antibody to a recombinant human cathepsin Z. |
| Specificity: | This antibody specifically reacts with the human cathepsin Z, but not with human cathepsins L, L2 and F on Western blotting. |
| Cross Reactivity: | Human. |
| Packaging: | 0.2 ml of purified immunoglobulin fraction in 0.1 M Na-Phosphate buffer, pH 7 containing 0.5% protease-free bovine serum albumin and 0.09% sodium azide as preservative. |
| Uses: | Western blotting. Other applications not tested. Optimal dilutions of this antibody are dependent on conditions and should be determined by the user. |
| Localization: | Lysosomal |
| Background: | Cathepsin family of proteases contains several diverse classes of enzymes. The cysteine protease class comprises cathepsin B, H, K, L, O, and S. The aspartyl protease class contains cathepsin D and E. Cathepsin G belongs to the serine protease class. Cathepsins are involved in various cellular events such as peptide biosynthesis, protein degradation, and apoptosis. Cathepsin Z (also known as preprocathepsin P and cathepsin X) is widely expressed in human tissues and cancer cells. It plays a role in normal cellular degradation and tumor progression. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. At least two transcript variants of this gene have been found, but the full-length nature of only one of them has been determined. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Isotype: | IgG1/k |
| Host Name: | Mouse |
| Buffer: | 0.1 M Na-Phosphate buffer, pH 7.0 containing 0.5% protease-free bovine serum albumin. |
| Application Summary: | Western Blot |
| Species Summary: | Hu |
| Alternate Names: | anti-AU019819 antibody, anti-AI787083 antibody, anti-Cathepsin P antibody, anti-Cathepsin X antibody, anti-Cathepsin X precursor antibody, anti-Cathepsin Z antibody, anti-Cathepsin Z precursor antibody, anti-CathepsinP antibody, anti-CathepsinX antibody, anti-CathepsinZ antibody, anti-CTSX antibody, anti-CTSZ antibody, anti-D2Wsu143e antibody, anti-Preprocathepsin P antibody, anti-PreprocathepsinP antibody |
| Package Size: | 0.2 ml |
| Product References: | 1. Santamaria, I., et al. Cathepsin Z, a novel human cysteine proteinase with a short propeptide domain and a unique chromosomal location. J. Biol. Chem., 273, 16816-16823, 1998. |
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