| item: | Rabbit Anti-Rab27A / B Antibody, Unconjugated |
| vendor: | Immuno-Biological Laboratories, Inc. |
| catalog number: | 18975 |
| quantity: | 100 µg |
| description: | Small GTPase Rab is a large family of membrane trafficking proteins that are conserved in all eukaryotic cells. More than 60 Rab isoforms have been reported in mice and humans, and they are believed to regulate various steps (or various types) of organelle transport. The Rab27 subfamily is phylogenetically similar to the Rab3 subfamily, and two Rab27 isoforms, Rab27A and Rab27B, are present in mice and humans. Mutations in the RAB27A gene cause human Griscelli syndrome, which is characterized by pigment dilution and immunodeficiency. The GTP-bound activated form of Rab27A regulates melanosome transport in melanocytes and secretory granule exocytosis (e.g., insulin secretion) through interaction with a specific effector molecule (e.g., Synaptotagmin-like protein (Slp) and Slac2). Rab27B is also expressed on secretory granules, the same as Rab27A, and regulates their exocytosis (e.g., amylase release from rat parotid acinar cells). |
| URL: | www.ibl-america.com/ab.html |
| catid: | 3194 |
| category name: | Antibodies |
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