| item: | Rabbit Anti-Human IRF-3 Antibody, Unconjugated |
| vendor: | Immuno-Biological Laboratories, Inc. |
| catalog number: | 18783 |
| quantity: | 100 µg |
| description: | Regulatory transcription factor IRF-3 plays a critical role in the regulation of innate immune responses, especially production of IFN-?/?, against viral and bacterial infections. IRF-3 is ubiquitously expressed in its inactive form in the cytoplasm. Viral infection induces phosphorylation of the Ser 386 in IRF-3 by IRF-3 kinase (IKK-i/epsilon, TBK-1). This phosphorylation induces dimerization of IRF-3 and association with the coactivators CBP/p300, and the complex activates the target genes in the nucleus. In addition, as this antibody is not suitable for western blotting by SDS-PAGE gel, we recommend Native-PAGE. |
| URL: | www.ibl-america.com/ab.html |
| catid: | 3194 |
| category name: | Antibodies |
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