| item: | Rabbit Anti-Human Osteopontin Polyclonal Antibody, Unconjugated |
| vendor: | Immuno-Biological Laboratories, Inc. |
| catalog number: | 18625 |
| quantity: | 100 µg |
| description: | Osteopontin (OPN) is a secreted glycoprotein that was originally isolated from bone. Its molecular weights have been reported in the range of 66 kDa to 44 kDa depending on glycosylation and phosphorylation. OPN is also known to be expressed in other fluids and tissues including milk, urine, activated T cells, smooth muscle cells, kidney and some tumor cells. OPN contains an Arg-Gly-Asp (RGD) amino acid sequence. This motif is present in fibronectin, vitronectin and a variety of other extra-cellular proteins that bind members of the integrin family of cell surface receptors such as a v beta 3. Recently OPN was identified as a ligand for CD44, which levels correlate with aggressiveness of lymphoid tumors and invasiveness of bladder carcinoma. Its interaction does not require RGD motif of OPN. In OPN knockout mice, it has been reported that a significantly decreased level of debridement was shown. Although the distribution and expression pattern of OPN in the human body have suggested the multiple function of OPN, its function under different situations remain obscure. |
| URL: | www.ibl-america.com/ab.html |
| catid: | 3194 |
| category name: | Antibodies |
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