| item: | | Rabbit Anti-Human CIS3 / SOCS-3 Monoclonal Antibody, Unconjugated, Clone C204 |
| vendor: | | Immuno-Biological Laboratories, Inc. |
| catalog number: | | 18393 |
| quantity: | | 100 µg |
| description: | | The Janus family of protein tyrosine kinases (JAKs) and STAT transcription factors regulate cellular processes involved in cell growth, differentiation, and transformation through their association with cytokine receptors. The CIS family of proteins (also referred as the SOCS or SSI family) has been implicated in the regulation of signal transduction by a variety of cytokines. The cytokine-inducible SH2 protein-3 (CIS3/SOCS-3/SSI-3) has been shown to inhibit the JAK/STAT pathway and act as a negative regulator of fetal liver erythropoiesis. Recently, it is reported that CIS3 regulates the erythropoietin (EPO) receptor (EPOR) signaling in erythroid progenitors and Ba/F3 cells expressing the EPOR (BF-ER). CIS3 binds directly to the EPOR as well as JAK2 and inhibits EPO-dependent proliferation and STAT5 activation. |
| URL: | | www.ibl-america.com/ab.html |
| catid: | | 3194 |
| category name: | | Antibodies |
| more information: | | company product webpage |
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